Therapeutic Approaches

Nosocomial infections are a major challenge for patient safety. Empirical antibiotic therapy should be based on careful clinical assessment and local epidemiological data regarding potential pathogens and antibiotic susceptibility. The chosen therapy should be effective, limit toxicity, and be the narrowest spectrum possible. The choice of antibiotic formulations parenteral, orally or topically is performed on the basis of clinical presentation (the site and severity of infection). Oral administration is preferred if possible. Antibiotic combinations should be used selectively and only for specific indications such as enterococcal endocarditis, tuberculosis and mixed infections. The doctor must decide whether antibiotic treatment is really necessary. In patients with fever, non-infectious diagnoses must be considered. Symptomatic treatment of shock, hypoventilation, and other complications should be provided, as well as broad-spectrum empiric antimicrobial therapy administration.

  • Evidence-Based Medicine
  • Advances in treatment of persistent nosocomial infections
  • Current and Future Treatment of Nosocomial Infections
  • Critical Care
  • Medical Care
  • Surgical Care
  • Wound Care
  • Monoclonal Antibody as an Anti-Infective
  • Research on antibiotic treatment and antibiotic de-escalation
  • Modification of Empiric Antibiotic Regimens
  • Appropriate Antibiotic Selection and Adequate Dosing
  • Combination Versus Monotherapy
  • Novel Therapeutic Strategies

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